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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK2
All Species:
31.82
Human Site:
Y252
Identified Species:
58.33
UniProt:
Q13177
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13177
NP_002568.2
524
58043
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Chimpanzee
Pan troglodytes
XP_516976
524
58004
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Rhesus Macaque
Macaca mulatta
XP_001099936
524
57950
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Dog
Lupus familis
XP_849432
524
57951
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIN4
524
57912
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Rat
Rattus norvegicus
Q64303
524
57942
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422671
521
57527
Y249
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Frog
Xenopus laevis
NP_001083738
517
57265
K247
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
S
G
Zebra Danio
Brachydanio rerio
NP_001020627
539
59696
Y267
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
F371
P
R
E
N
L
D
H
F
N
K
I
G
E
G
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
V298
P
D
R
K
Y
R
K
V
D
K
I
G
S
G
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
L623
P
S
T
K
Y
A
N
L
V
K
I
G
Q
G
A
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
F677
P
R
E
I
Y
R
G
F
T
K
I
G
Q
G
A
Conservation
Percent
Protein Identity:
100
99.6
99
96.7
N.A.
97.1
96.9
N.A.
N.A.
92.7
87.2
83.8
N.A.
34.4
N.A.
53.3
N.A.
Protein Similarity:
100
99.6
99.2
98.2
N.A.
98.4
98.2
N.A.
N.A.
95.6
92.5
89
N.A.
50.5
N.A.
68.5
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
13.3
100
N.A.
33.3
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
13.3
100
N.A.
66.6
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
32.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42.4
42.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
85
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
8
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
16
0
0
0
8
0
62
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
8
0
100
0
93
8
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
8
0
93
0
0
0
0
% I
% Lys:
8
70
62
77
0
0
8
8
0
93
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
8
0
0
0
0
0
0
% N
% Pro:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
77
0
0
% Q
% Arg:
0
16
8
0
8
16
62
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
0
0
0
0
0
8
8
8
% S
% Thr:
0
0
8
8
0
62
0
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
85
8
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _